diff --git a/Utilities/Python/vtkPython.h b/Utilities/Python/vtkPython.h
index 2fe0ac96..621b5446 100644
--- a/Utilities/Python/vtkPython.h
+++ b/Utilities/Python/vtkPython.h
@@ -37,7 +37,6 @@
 #include <sys/stat.h>
 #include <time.h>
 #include <wchar.h>
-#undef _DEBUG
 #if defined(_MSC_VER)
 #define _CRT_NOFORCE_MANIFEST 1
 #endif